The lower Dong Nai - Sai Gon river basin plays a significant role in Vietnam's economic development. In the basin, Ho Chi Minh (HCM) City is known as the biggest center with a fast growing economy and increasing population. However, this area is undergoing inundation problems caused by upstream floods, heavy rains and changes in sea levels. Flooding control in this area has been subject to many studies and thus a number of measures was proposed, such as the hydraulic construction system (1547/QĐ-TTg), sea dike from Vung Tau to Go Cong, sea dike from Can Gio to Go Cong and so on. However, the effectiveness of such measures have not been analyzed and compared. This study applies one large scale 1-D hydrodynamic model and GIS techniques to clarify and assess the ability of flood control measures. Three sea level rise scenarios for Vietnam are also taken into account. The computed results with sea level rise show that the current hydraulic construction system (1547/QĐ-TTg) can control floods but in the future, an integrated measure with the Can Gio - Go Cong sea dike is the most effective one in controling flood in this area.